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The abbreviation UPA has several meanings:

• United Productions of America, USA-based animation studio
• Ukrayinska Povstanska Armia (Ukrainian Insurgent Army), a Ukrainian nationalist partisan organization during and after the World War II
• Uralic Phonetic Alphabet
• The Uniform Partnership Act, a model statute proposed by the National Conference of Commissioners on Uniform State Laws (NCCUSL).
• United Progressive Alliance A political coalition ruling India, since 2004
• University Preparatory Academy of Seattle, Washington, USA
• Ultimate Players Association, governing body of the sport of Ultimate in North America
• urokinase type Plasminogen Activator (uPA), an enzyme important in lysis of blood clots
• Usability Professionals' Association, a body supporting "those who promote and advance the development of usable products".

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