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Uno can mean:

• The number one in Spanish, Italian, and other Romance languages
• A card game played with a special deck of cards. It is made by the Mattel company.
• A loosely franchised restaurant chain in the U.S. called Uno Chicago Grill.
• Unniloctium (Uno), the former name of the chemical element Hassium (Hs), element 108

UNO is an abbreviation for:

• The United Nations Organization; see: United Nations
• The University of New Orleans
• The University of Nebraska at Omaha
• Universal Network Objects, the software component for the OpenOffice.org office suite.
• Ukrainian Nationalist Organisation, led by Stepan Bandera.
• The United Nicaraguan Opposition, formerly led by Violeta Barrios de Chamorro.
• Underground Nucleon Decay and Neutrino Observatory, proposed physics laboratory.

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