There have been several notable individuals with the name Robert Blake:
- Admiral Robert Blake (1599-1657), English military commander of the 17th Century.
- Dr Robert Blake (1772-1822), pioneering Irish dentist
- Robert Blake, the first African-American to win the Medal of Honor
- Robert Blake, Baron Blake (1916-2003), noted British historian
- Robert O. Blake (b. 1921), ambassador and diplomat
- Robert Blake (b. 1933), actor of TV's Baretta
- Robert R. Blake (1918-2004), developed the Managerial Grid Model
- Rob Blake (b. 1969), professional ice hockey player
- Robert Blake, a character from Bungie's computer game Marathon 2: Durandal
- Robert Blake, a fictional character from H. P. Lovecraft's short story "The Haunter of the Dark" who was based on Robert Bloch.
- Robert Blake, folksinger from the Pacific Northwest who recorded a split lp with Erik Peterson