Potomac may refer to:
- Potomac River, which flows through West Virginia, Maryland, Virginia, and Washington, DC, USA
- Potomac, an unincorporated area in Montgomery County, Maryland, USA
- Potomac, a village in Vermilion County, Illinois, USA
- Potomac Park, Maryland
- Potomac Airfield, a general aviation airport located in Fort Washington, Maryland
- Potomac, a tribe of Native Americans
- A general term given to the Washington, D.C./Maryland metropolitan area
- One of several US Navy ships, including:
In addition, Potomac Street is a major arterial in Aurora, Colorado.